9/5/2023 0 Comments Inr antidote![]() ![]() The current IV vitamin K preparation can be given as an IV push over 2-3 mins.Įffects of INR from IV vitamin K seen within 4 hours, for oral vitamin K 12-24 hours. If the INR falls significantly below the therapeutic range additional anticoagulant therapy should be considered for patients with a high risk of thrombosis. This protocol gives relatively aggressive reversal of warfarin. Patient with an INR above the therapeutic range with a high risk of bleedingĦ-12 hours early testing may be necessary if INR excessively above 9 or risk of bleeding assessed as very high. May offer advantage over FFP as a small volume and there is no time delay in thawing. The INR can be measured within 15mins of dose completion and doses repeated as necessary depending on the INR. WarfarinĢ5-50 IU/kg Octaplex plus 2 units of FFP if Octaplex not readily available 4 units FFP.Īssess patient continuously until both INR 5.0 use a dose closer to 50IU/kg.Īdminister at a rate of 3ml/min or as tolerated by the patient. It is for any clinically significant bleeding where warfarin induced coagulopathy is considered a contributing factor. This intervention is designed to rapidly reverse the INR in what may be life-threatening circumstances. Patient has clinically significant bleeding ![]() There is a smart phone app available to assist with managing over dose. If a patient has a high INR consider the following possible causesĪn elevated INR can significantly increase the risk of death from haemorrhage Smart Phone app Treatment strategy for warfarin over-anticoagulation
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